Project Jake surveyed the use and safety of isoxazoline parasiticides given to dogs. Data were received from 2751 respondents during one month in 2018; 58% (1594) had been treated with some product for flea control, and of those, 83% (1325) received an isoxazoline. Adverse events were reported for 66.6% of respondents. Findings were compared retrospectively to publicly available FDA and EMA reports. Serious events of death, seizures and neurological effects reported in the Jake survey were higher than the FDA but lower than the EMA. Although product labels have recently been updated, dogs and cats remain impacted by their use. Dr Dodds will also discuss other options including flea combs, bathing, vitamin supplements and diatomaceous earth.